Diabetes and Glutathione
How does Diabetes and Glutathione relate to and affect one another?
Diabetics have high levels of oxidative stress, which basically means too many free radicals and not enough antioxidants to neutralize them.
Diabetics also have low levels of intracellular glutathione (GSH).
The high levels of oxidative stress and the low glutathione (GSH) levels further complicates the diabetic state which leads to even higher levels of oxidative stress and even lower levels of GSH.
It would be beneficial for anyone suffering from Diabetes to increase their antioxidant supplementation. Glutathione, being the master antioxidant, would naturally be the best choice.
Furthermore, inflammation leads to and contributes to insulin resistance. Glutathione, on top of being the most potent antioxidant, is also a powerful ant-inflammatory.
"Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. Free radicals are formed disproportionately in diabetes ….Abnormally high levels of free radicals and the simultaneous decline of antioxidant defense mechanisms can lead to ….development of insulin resistance. These consequences of oxidative stress can promote the development of complications of diabetes mellitus." © 2003 Wiley Periodicals, Inc. J Biochem Mol Toxicol 17:24-38, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.10058
"…there is evidence for increased oxidative stress in diabetes….With regard to diabetes, antioxidants…supplementation have been shown to be beneficial…Thus, it appears that, in diabetes, antioxidant therapy could alleviate the increased attendant oxidative stress and emerge as an additional therapeutic modality." Vega-Lopez S, Devaraj S, Jialal I: Oxidative stress and antioxidant supplementation in the management of diabetic cardiovascular disease. J Investig Med 2004, 52(1):24-32. PubMed
"Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered that inflammation…leads to insulin resistance and Type 2 diabetes." ScienceDaily (Nov. 7, 2007)
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Knowing diabetes and its effects. This site is also meant to help people understand all aspects of their diabetes, and therefore gain a lot of knowledge about this complex disease.
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